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Barry Sharpless
  • 2001 Nobel Prize in Chemistry

Intro

American chemist,M. Keck Professor of the Scripps Institute, known for his work on stereoselective reactions and click chemistry. He won the 2001 Nobel Prize in Chemistry for his outstanding contribution to the study of Chiral Catalytic Oxidation.

Education and Work Experience

1968, Ph.D, Stanford University
1980-1990, Professor, Massachusetts Institute of Technology 1990-Present, Professor, Scripps Institute, USA

Honors and Awards

1985,Member of the American Academy of Sciences; 1984,Member of the American Academy of Arts and Sciences;
2001,Wolf Prize Winner
2001 Nobel Prize in Chemistry 2019, Priestley Medal

Major Academic Achievements

Professor Sharprless developed a stereoselective oxidation reaction. He found chemical reactions such as amino-hydroxylation, dihydroxylation and asymmetric epoxidation. Sharpless asymmetric epoxidation is an asymmetric selective chemical reaction that can be used to produce 2o 3-epoxide from primary or secondary allyl alcohols and has been used to synthesize carbohydrates terpenes leukotrienes pheromones and antibiotics. The asymmetric dihydroxylation reaction is one of the most important reactions in modern organic synthesis.Click Chemistry is a synthetic concept initially proposed by Sharpless in 1998 and further developed in 2001. Its main aim is to quickly and reliably complete the chemical synthesis of all kinds of molecules through connecting modulars via few perfect reactions. More recently, the Sharpless team has developed a new generation of click-chemistry reactions, Sulfur(VI) fluoride exchange(SuFEx)chemistry. The reaction has great potential for applications in areas such as material science and drug discovery. Professor Sharpless could win a second Nobel Prize based on his groundbreaking achievements in Click Chemistry.