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William Kaelin, Jr.
  • 2019 Nobel Prize in Physiology or Medicine

Intro

2019 Nobel Prize in Physiology or Medicine
Professor in the Department of Medicine at the Dana- Farber Cancer Institute, Harvard Medical School, and Associate Director, Basic Science, for the Harvard Cancer Center, a member of the American Society of Clinical Investigation and the Institute of Medicine (IOM). He recently served on the National Cancer Institute Board
of Scientific Advisors, the AACR Board of Trustees, and the IOM National Cancer Policy Board. He was awarded the 2019 Nobel Prize in Physiology or Medicine "for the discoveries of how cells sense and adapt to oxygen availability."

Education and Work Experience

2010 年,美国国家科学院,院士
2010 年,加拿大盖尔德纳国际奖
2016 年,拉斯克基础医学研究奖
2019 年,诺贝尔生理学或医学奖

Honors and Awards

2010, National Academy of Sciences
2010, Canada Gairdner International Award
2016, Albert Lasker Basic Medical Research Award 2019, Nobel Prize in Physiology or Medicine

Major Academic Achievements

Dr. Kaelin's research seeks to understand how, mechanistically, mutations affecting tumor- suppressor genes cause cancer. His long-term goal is to lay the foundation for new anticancer therapies based on the biochemical functions of tumor suppressor proteins. His work on the VHL protein helped to motivate the eventual successful clinical testing of VEGF inhibitors for the treatment of kidney cancer. Moreover, this line of investigation led to new insights into how cells sense and respond to changes in oxygen, and thus has implications for diseases beyond cancer, such as anemia, myocardial infarction and stroke.